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2012/716 RNA interference (RNAi) as a means to control Neoparamoeba perurans, the causative agent of amoebic gill disease (AGD) (Paula Lima)
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2012/716 RNA interference (RNAi) as a means to control Neoparamoeba perurans, the causative agent of amoebic gill disease (AGD) (Paula Lima)



By Paula Lima

 

RNA interference has emerged as a powerful tool for rapid analysis of gene function in non-model organisms and has the potential to identify candidate targets for intervention against diseases of economic importance to aquaculture. The main purpose of the study was to use functional and comparative genomics approaches to investigate whether the RNAi mechanism has been retained or lost in species from the Neoparamoeba genus.

 

The results provide strong evidence that both infective and non-infective species from Neoparamoeba spp. have evolutionarily retained key genes involved not only in the canonical RNAi mechanism, but also in the miRNA and piRNA pathways. Despite being promising, these findings are still preliminary and the reality of applying RNAi technology to develop new treatment strategies against AGD still needs further effort.